Digestive Health Associates

Southwest Endoscopy Center

IBD Vaccination


This guideline is intended to be an educational device to provide information that may assist us in providing care to patients. This guideline is not a rule and should not be construed as establishing a legal standard of care or as encouraging, advocating, requiring, or discouraging any particular treatment. Clinical decisions in any particular case involve a complex analysis of the patient’s condition and available courses of action. Therefore, clinical considerations may lead a physician to take a course of action that varies from this guideline.

Vaccination history to consider:
-tetanus (Tdap)
-diphtheria (Tdap)
-pertussis (Tdap)
-HPV
-influenza
-hepatitis A
-hepatitis B
-meningococcal
-MMR
-varicella
-H. zoster

Laboratory studies:
-RUBEOLA, MUMPS, RUBELLA IGG ANTIBODIES (PAML | MMRG)
-VARICELLA-ZOSTER ANTIBODY, IgG (PAML | VZA)
-HEPATITIS A VIRUS ANTIBODY, TOTAL (PAML | HAVAB)
-HEPATITIS B SURFACE ANTIBODY (PAML | HBSAB)

Vaccines to consider in specific patient groups regardless of immunosuppressive drug use:
-Tdap (tetanus, diphtheria, pertussis)
-HPV (select populations)
-influenza
-pneumococcal
-hepatitis A
-hepatitis B
-meningococcal
 
Vaccines to consider if no plans to start immunosuppressive therapy in 4-12 weeks:
-MMR*
-Varicella*
-H. zoster (select populations)*
 
*live vaccines (avoid immunomodulators and TNF-inhibitor for 4-12w)
 
Adapted from:
Wasan SK, Baker SE, Skolnik PR, Farraye FA. A practical guide to vaccinating the inflammatory bowel disease patient. Am J astroenterol. 2010 Jun;105(6):1231-8. Epub 2010 Jan 26. Review. PubMed PMID: 20104218.

Additional information regarding zoster vaccination and immunosuppressive therapy
Zoster vaccination should be deferred for at least 1 month after discontinuation of high dose corticosteroid therapy (≥20 mg/day of prednisone or equivalent.  Zoster vaccination is not contraindicated by low-does of methotrexate (≤0.4 mg/Kg/week), azathioprine (≤3 mg/Kg/day), 6-mercaptopurine (≤1.5 mg/Kg/day).